Day one
Date: Tuesday 19 May (Day one)
Place: Virtual Meeting held via Microsoft Teams
Present members:
- Professor Joy Adamson
- Dr Ben Ainsworth
- Mr Paul Charlton
- Professor Saul Faust
- Dr Emilio Fernandez-Egea
- Professor Steve Goodacre
- Professor Richard Grieve
- Dr Rebecca Harmston
- Professor Angela Hassiotis
- Professor Catherine Hewitt
- Professor Pip Logan
- Professor Jane Nixon
- Mr Daniel Perry
- Professor Chris Rogers
- Professor Sobha Sivaprasad
- Dr Chris Sutton
- Professor Catrin Tudur-Smith
- Dr Katrina Turner
- Professor Hywel Williams
- Professor Nefyn Williams
NETSCC, HTA Secretariat:
- Dr Nick Hicks (Consultant Advisor)
- Steph Garfield-Birkbeck (Head of the HTA Programme)
- Mrs Vicky Taylor (Assistant Director)
- Ms Kathy Tier (Research Manager)
- Helen Munday (Research Manager)
- Mrs Karen Williams (Senior Research Manager) – AM only
- Miss Constance Temple-Brown (Assistant Research Manager)
- Miss Louisa Saunders (Assistant Research Manager)
- Miss Alessandra Wilkinson-Smith (Assistant Research Manager)
Apologies:
- Professor Gary Collins
- Mr Rakesh Heer
- Professor Nick Maskell
- Professor Jonathan Ross
- Professor Andrew Shennan
- Dr Greta Rait
- Professor Rebecca Reynolds
Observers:
- Professor Andrew Farmer – HTA General Funding Committee Chair
- Dr Amy Halls (Research Manager – Identification and Prioritisation, NETSCC)
- Dr Brogan Ashley (Research Manager – Application and Funding, NETSCC)
- Mrs Jane Mooney (Administrator – Application and Funding, NETSCC)
Commissioned Stage 2 shortlisted at January 2020 Committee
19/41 Clozapine for children and young people with treatment resistant schizophrenia
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Dr Emilio Fernandez-Egea, Professor Angela Hassiotis
NIHR131175: CLEAR: (CLozapine in EARly psychosis) A Multi-Centre, Randomised Controlled trial of Clozapine for Young People with Treatment Resistant Psychosis in Real World Settings (Professor James MacCabe, Kings College London)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/43: Amitriptyline for the prevention of post-herpetic neuralgia
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Ben Ainsworth, Dr Katrina Turner, Professor Chris Rogers, Professor Daniel Perry, Professor Hywel Williams
NIHR129720: ATHENA: AmiTritypline for the prevention of post-HErpetic NeuralgiA (Dr Matthew Ridd, University of Bristol)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131035: Prevention of Shingles Pain Trial (PROSPECT) (Professor Julie Bruce, University of Warwick)
Funding Committee recommendation: Decline
19/44: Nutrient enriched diet for babies with a brain injury
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: None
NIHR130925: Investigating the clinical and cost-effectiveness of a nutrient enriched diet for babies with a brain injury: The Dolphin Randomised controlled trial (Professor Jeremy Parr, University of Newcastle upon Tyne)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/77: Monitoring and follow-up for adults with hearing loss
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Professor Hywel Williams
NIHR131159: Follow-up and structured monitoring for adults offered a NHS hearing aid for the first time (FAMOUS): a cluster randomised controlled trial (Professor Kevin Munro, The University of Manchester)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/78: Ambulatory oxygen therapy in idiopathic pulmonary fibrosis
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Rebecca Reynolds
NIHR130294: A phase III parallel group randomized controlled multi-centre trial to evaluate effects of ambulatory oxygen on quality of life and its cost-effectiveness in patients with idiopathic pulmonary fibrosis and isolated exertional hypoxia. (Dr Elisabetta Renzoni, Royal Brompton & Harefield NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR131149: Ambulatory oxygen for pulmonary fibrosis (OxyPuF) (Dr Alice Turner, University of Birmingham)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/79: Idiopathic intracranial hypertension
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Emilio Fernandez-Egea, Professor Chris Rogers, Professor Daniel Perry, Professor Nefyn Williams
NIHR130823: Randomised Evaluation of Venous Intervention versus Shunting in IIH with Optic Nerve disc swelling (REVISION (Miss Catherine McMahon, The Walton Centre NHS Foundation Trust)
Funding Committee recommendation: Decline
NIHR131211: Intervention To Preserve Vision In Idiopathic Intracranial Hypertension: Evaluation Of Clinical Effectiveness And Cost Effectiveness (Professor Alexandra Sinclair, University of Birmingham)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/80: Posterior decompressive surgery with fixation for degenerative cervical myelopathy
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Emilio Fernandez-Egea
NIHR131243: FUSION 4 DCM: Posterior decompressive surgery with fixation for multi-level degenerative cervical myelopathy (Dr Mark Kotter, University of Cambridge)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/75: Stem cell transplant for adults with severe sickle cell disease
Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Professor Hywel Williams, Professor Steve Goodacre
NIHR130674: Randomised trial of Haploidentical Transplantation compared to standard of care for Adults with Sickle Cell Disease (Dr Victoria Potter, King's College Hospital NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/82: Conservative management of odontoid fracture in the elderly: to immobilise or not?
Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Professor Rebecca Reynolds, Professor Steve Goodacre
Left meeting: Saul Faust
NIHR131118: DENS RCT: Duration of External Neck Stabilisation following odontoid fracture in older or frail adults: a randomised controlled trial of collar versus no collar (Mr Paul Brennan, The University of Edinburgh)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131230: Conservative management of odontoid fractures in the elderly. To immobilise or not? (Professor Antonio Belli, University of Birmingham)
Funding Committee recommendation: Decline
Day two
Date: Tuesday 20 May (Day two)
Place: Virtual Meeting held via Microsoft Teams
Present members:
- Professor Joy Adamson
- Dr Ben Ainsworth
- Mr Paul Charlton
- Professor Saul Faust
- Dr Emilio Fernandez-Egea
- Professor Steve Goodacre
- Professor Richard Grieve
- Dr Rebecca Harmston
- Professor Angela Hassiotis
- Professor Catherine Hewitt
- Professor Jane Nixon
- Mr Daniel Perry
- Professor Chris Rogers
- Professor Sobha Sivaprasad
- Dr Chris Sutton
- Professor Catrin Tudur-Smith
- Dr Katrina Turner
- Professor Hywel Williams
- Professor Nefyn Williams
NETSCC, HTA Secretariat:
- Dr Nick Hicks (Consultant Advisor)
- Ms Kathy Tier (Research Manager)
- Helen Munday (Research Manager) – AM only
- Mrs Karen Williams (Senior Research Manager) – PM only
- Miss Constance Temple-Brown (Assistant Research Manager)
- Miss Louisa Saunders (Assistant Research Manager)
- Miss Alessandra Wilkinson-Smith (Assistant Research Manager)
Apologies:
- Professor Gary Collins
- Mr Rakesh Heer
- Professor Nick Maskell
- Professor Jonathan Ross
- Professor Andrew Shennan
- Dr Greta Rait
- Professor Pip Logan
- Professor Rebecca Reynolds
Observers:
- Professor Andrew Farmer – HTA General Funding Committee Chair
- Dr Brogan Ashley (Research Manager – Application and Funding, NETSCC)
Commissioning Stage two Continued
19/84: Surgical treatment for severe stable slipped capital femoral epiphysis (SCFE) in children
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Daniel Perry, Professor Nefyn Williams, Professor Catrin Tudur Smith
NIHR131176: The British Orthopaedic SCFE Surgery Study for Severe Stable Slips (The Big BOSS Study): A multi-centre prospective randomised superiority trial of an acute deformity correction versus pinning in-situ for severe stable SCFE in children. (Professor Daniel Perry, University of Liverpool)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/85: Anti-reflux medication to reduce stricture formation following oesophageal atresia repair
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Nefyn Williams, Professor Saul Faust
Left meeting: Professor Saul Faust
NIHR131136: Treating Oesophageal Atresia to prevent STricture (TOAST) (Associate Professor Nigel Hall, University of Southampton)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/42: Selective serotonin reuptake inhibitor to prevent depression following traumatic brain injury
Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Dr Emilio Fernandez-Egea, Professor Hywel Williams, Professor Rebecca Reynolds, Professor Steve Goodacre, Professor Catrin Tudur Smith
NIHR130879: RandomIsed COnTrol Trial Anti depressants in Traumatic Brain Injury. RICOTTA-TBI (Mr Adel Helmy, University of Cambridge)
Funding Committee recommendation: Decline
NIHR131125: A multi-centre randomised controlled trial of the clinical and cost-effectiveness of sertraline in preventing depression in adults following a traumatic brain injury (Professor Khalida Ismail, King's College London)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/86: Thromboprophylaxis in pregnancy and after delivery
Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Dr Katrina Turner, Professor Catrin Tudur Smith, Professor Chris Rogers, Professor Hywel Williams, Professor Steve Goodacre
NIHR131021: Estimating the value of future research to improve guidelines on thromboprophylaxis for women during pregnancy and after delivery (Ms Sarah Davis, The University of Sheffield)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
NIHR131131: VISMAT- Value of Information: Studying MAternal Thromboprophylaxis. The expected return on investment from a study of risk assessment for, and prevention of, venous thromboembolism during and immediately after pregnancy: a systematic review, economic eva (Dr Edward Wilson, University of East Anglia)
Funding Committee recommendation: Decline
19/87: Night-time only bracing for scoliosis
Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Professor Daniel Perry, Professor Nefyn Williams, Professor Steve Goodacre, Catrin Tudur Smith
Arrived at the meeting: Mr Paul Charlton, Professor Saul Faust
NIHR131081: Night-time Only Bracing in Adolescent Idiopathic Scoliosis Trial (NOBAIST) (Mr Ashley Cole, Sheffield Children's NHS Foundation Trust)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
19/88: Ablative and non-invasive therapies for hepatocellular carcinoma
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Catherine Hewitt, Professor Catrin Tudur Smith
NIHR131224: Ablative and non-invasive therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis (Professor Alison Eastwood, University of York)
Funding Committee recommendation: Straight Fund
19/151: HTA Solid Organ Replacement, Transplant And Donation
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Emilio Fernandez-Egea, Professor Philippa Logan
NIHR131124: Statins in Organ Donor Management. An evaluation of the benefits of a single dose of Simvastatin given to potential organ donors declared dead by neurological criteria on outcomes in organ recipients. SIGNET Statins for Improving orGan outcomE in Transplan (Professor John Dark, University of Newcastle upon Tyne)
Funding Committee recommendation: Programme Oversight Committee to consider fund with changes
Commissioning Stage 1
19/123: Oxybutynin for the treatment of vasomotor symptoms in menopause
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Professor Hywel Williams, Professor Philippa Logan
NIHR131635: Oxybutynin or antidepressants for hot flushes in women who cannot or choose not to use hormone replacement therapy: randomised trial and economic evaluation (the BLUSH trial) (Dr Melanie Davies, University College London Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
19/127: Surgery for endometrioma in women undergoing IVF
Chair: Professor Catherine Hewitt
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Professor Hywel Williams, Professor Rebecca Reynolds, Professor Steve Goodacre
Left the meeting: Professor Saul Faust
NIHR131366: Surgery for endometrioma: SEnd (Dr Abha Maheshwari, NHS Grampian)
Funding Committee recommendation: Decline Return to POC
19/129: Lumbar fusion for low back pain
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Christopher Sutton, Dr Katrina Turner, Professor Chris Rogers, Professor Nefyn Williams
Arrived at the meeting: Professor Andrew Shennan
Left the meeting: Professor Catrin Tudur-Smith
NIHR131405: SIngle Level Lumbar fusion VERsus Functional ReSToration (SILVERFROST) (Mr Jason Bernard, St George's University Hospitals NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
NIHR131531: The clinical and cost-effectiveness of lumbar fusion surgery for patients with persistent, severe low back pain: the PICASO trial (Professor Nadine Foster, Keele University)
Funding Committee recommendation: Decline Return to POC
NIHR131772: A covariate adaptive randomised, multi-centre trial of instrumented lumbar fusion surgery versus Combined Physical and Psychological Program (CPPP) for the treatment of nociceptive and neuropathic low back pain in adults- comparing clinical outcomes and cost-effectiveness (Mr Birender Balain, The Robert Jones and Agnes Hunt Orthopaedic Hospital NHS Foundation Trust)
Funding Committee recommendation: Decline Return to POC
19/125: Cardiac rehabilitation for stable angina
Chair: Professor Steve Goodacre
Declared a conflict and did not partake in the discussion or vote: Dr Ben Ainsworth, Dr Christopher Sutton, Professor Catherine Hewitt, Professor Daniel Perry, Professor Joy Adamson, Professor Philippa Logan
Declared a conflict and left the call: Professor Nefyn Williams,
NIHR131014: Cardiac Rehabilitation for Stable Angina (CReST) trial (Dr Gordon McGregor, University Hospitals Coventry & Warwickshire NHS Trust)
Score: 10 voted yes, 0 voted no
Funding Committee recommendation: Shortlist
NIHR131015: Cardiac rehabilitation for people with chronic stable angina: a randomised controlled trial. Acronym: Angina Controlled Trial Investigating the Value of the 'Activate your heart' Therapeutic E-intervention (ACTIVATE) (Professor Nefyn Williams, University of Liverpool)
Score: 10 voted yes, 0 voted no
Funding Committee recommendation: Shortlist
NIHR131714: A randomised controlled trial of a supported digital rehabilitation intervention in patients with stable angina: the REACH-AP Study (Professor Rod Taylor, University of Glasgow)
Score: 1 voted yes, 8 voted no
Funding Committee recommendation: Decline
NIHR131742: Randomised controlled trial of the clinical and cost-effectiveness of Cardiac REhabilitation for STable Angina: the CRESTA trial (Professor Patrick Doherty, University of York)
Score: 0 voted yes, 10 voted no
Funding Committee recommendation: Decline
NIHR131778: Patient-Centred Design and Evaluation of a Scalable Digital Cardiac Rehabilitation Programme (Dr Rasha Al-lamee, Imperial College London)
Funding Committee recommendation: Decline